Orai1 and STIM protein expression is impaired in H123 cells. A, STIM1 ...
The inhibitory action of Synta66 is affected by Orai1 pore geometry ...
Mutations in Orai1 that cause constitutive channel activity and/or ...
ORAI1 C126R is defective in bilayer insertion. a Representative traces ...
The effect of ORAI1 inhibition in breast cancer cells. A, ORAI1 was ...
A schematic representation of STIM1 (A) and Orai1 (B) mutants used in ...
SOAR Mutants 4KA or F394H Interact with ORAI1 Channels in a ...
Inhibition of Orai1 and SOCE reduced IL-6 expression in cervical cancer ...
Loss of ORAI1 signaling in cardiomyocytes leads to impaired calsarcin ...
Impaired effector function of Orai1 KI/KI T cells in vitro | Download ...
Blockage of Store-Operated Ca2+ Influx by Synta66 is Mediated by Direct ...
Inhibition of SOCE in GBM cell lines by Synta66: (A) Western blot for ...
Orai1 Plays a Crucial Role in Central Sensitization by Modulating ...
Effect of Orai1 inhibition and expression of the STIM1 (K684,685E ...
PKC-Mediated Orai1 Channel Phosphorylation Modulates Ca2+ Signaling in ...
Deletion of Orai1 Impairs Synaptically Evoked Ca 2+ Signals in ...
JCI Insight - ORAI1 inhibition as an efficient preclinical therapy for ...
The Orai1 K85E mutation abolished 2-APB’s inhibition on STIM1-bound ...
Inhibition of ATP-induced store-operated Ca²⁺ entry by Synta66 and ...
Orai1 internalization and STIM1 clustering inhibition modulate SOCE ...
Inhibition of RAC1 impaired cell motility and reduced co-precipitation ...
CRAC channel blocker Synta66 inhibits x-ray–stimulated increase in ...
| Synta66 inhibits SP-induced Ca 2+ influx and degranulation in Human ...
| Synta66 Attenuates SP-Induced Murine MC Responses in vitro and in ...
Figures and data in A pathogenic human Orai1 mutation unmasks STIM1 ...
S417 in the CC3 region of STIM1 is critical for STIM1-Orai1 binding and ...
Increase in pore radius fails to restore activity of SCID-related ORAI1 ...
Schematic diagram of the Orai1 mutants with truncations or point ...
Differential Roles of the C and N Termini of Orai1 Protein in ...
Ectopic Orai1 expression promotes csc phenotype in non-tumorigenic ...
Orai1 inhibition ameliorates acinar and ductal functions. (A ...
ORAI1 and STIM1 deficiency in human patients and mice. a Situation in ...
Upregulation of ORAI1 expression after pathological challenge in mice ...
Site-specific incorporation of Azi and Bpa in Orai1 a Chemical ...
Effect of Orai1 inhibition osteoblast differentiation | Download ...
ORAI1 Activates Proliferation of Lymphatic Endothelial Cells in ...
Altered expression of Orai1 and STIM1 and relocalisation of STIM1 in ...
Single point coiled-coil mutants of Orai2 and Orai3 contrary to Orai1 ...
STIM1 interacts with the non-functional Orai1 CBD-TM4 linker mutants ...
A novel mutation in ORAI1 presenting with combined immunodeficiency and ...
The Orai1 pore mutant E106D is amplified by, but largely protected ...
Expression of glycosylation-deficient mutants of Orai1 and STIM1 ...
(PDF) ORAI1 inhibition as an efficient preclinical therapy for tubular ...
Selective Deletion of Orai1 in Excitatory Neurons Also Impairs Learning ...
Orai1 calcium channel inhibition prevents progression of chronic ...
| Synta66 inhibits SOCE. (A) Representative traces of SOCE in response ...
Frontiers | ORAI1 Ca2+ Channel as a Therapeutic Target in Pathological ...
ORAI1 regulates processes important for cancer cell proliferation ...
| Protein domain structure of human ORAI1 and the reported ORAI1 ...
ORAI1-Regulated Gene Expression in Breast Cancer Cells: Roles for STIM1 ...
STIM1 interaction is not affected by Synta66: (A) Localization, overlay ...
Orai1 ⌬ 277–279 deletion mutant exhibits increased coiled-coil ...
Synta66 had differential effects on FceRI stimulated Prostaglandin D2 ...
Overexpression of Orai1 and STIM1 Proteins Alters Regulation of Store ...
STIM1 modulates the activity of photocrosslinking UAA-containing Orai1 ...
Orai1 and STIM1 move to the immunological synapse and are up-regulated ...
Deletion of Orai1 Alters Expression of Multiple Genes during Osteoclast ...
The Orai1 Severe Combined Immune Deficiency Mutation and Calcium ...
Synta66 and 2-APB inhibit egress of live JUNV (Candid-1 strain) from ...
Synta66 significantly inhibited FceRI stimulated histamine and TNFa ...
Models of STIM1-induced activation of Orai1 channels. (A) Cartoon ...
Regulation of neuropathic pain by microglial Orai1 channels | Science ...
Frontiers | Inhibition of Orai Channel Function Regulates Mas-Related G ...
ORAI1 deficiency and lack of store-operated Ca2+ entry cause ...
STIM1 DQ mutant down-regulates Orai1 protein and expression of ...
Effects of miR-93-5p mimic and inhibitor on the expression of Orai1 ...
Both intracellular termini of Orai1 are indispensable for STIM1 ...
Effect of Orai1 on translocation of Orai2 and Orai3 to the immune ...
Identification of Orai1 Channel Inhibitors by Using Minimal Functional ...
Photocrosslinking of Orai1 TM domains can lead to CRAC channel-like ...
Orai1 overrules inhibitory effect of CaM mutants: (A) Block diagram ...
Severe impairment of I CRAC in differentiated ORAI1-deficient T cells ...
ORAI1 R91W SCID mutant displays loss of Ca 2 ؉ current activity despite ...
Investigation of ORAI1 mutant T cell calpain activity and migration ...
Orai1 E173K restores the gating defieciency of STIM1 α3 mutants. A time ...
The ORAI1 N-and C-Terminal Regions Are Required for Recruitment of ...
Ca 2 + dependence of E106D Orai1 mutant gating (A) Apparent P o curves ...
Overexpression of STIM1 and/or ORAI1 promotes cell senescence. A. β-Gal ...
Orai1 Inhibitors as Potential Treatments for Pulmonary Arterial ...
Orai1 internalization endocytic pathway. (A) Oocytes expressing ...
Truncation of the N terminus of Orai1 reduces FRET between ...
Orai and TRPC channel characterization in FcεRI‐mediated calcium ...
| Disruption of the Orai1 N-terminal M1-ext compromises pore function ...
ORAI1/STIM1 Interaction Intervenes in Stroke and in Neuroprotection ...
Thiol dependent intramolecular locking of Orai1 channels | Scientific ...
Orai1 mutations. The subunit schemes display so far discovered ...
Inhibition of Orai1-mediated SOCE downregulated c-KIT protein ...
Assessment of the effect of Synta66 and YM58483 on a complete media ...
Pharmacological effect of Synta66 and 2-APB on egress of filovirus ...
Block of inhibition of SOCE and effects of WT and mutant Orai ...
Orai channels contribute to Müller glial SOCE. A, Comparison of store ...
Graphical schematic summarizes the regulation of ORAI1-mediated Ca 2 ...
ORAI1, STIM1/2, and RYR1 shape subsecond Ca2+ microdomains upon T cell ...
Overexpression of TaABC1K3 and TaABC1K6 alleviated the photosynthesis ...
OASF L373S mutant exhibits disrupted coupling to as well as activation ...
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels ...
LoCEs are inhibited by SOCE and ORAI inhibitors. (A) Representative ...
2-APB induced STIM1-CT mutant (S417G)-Orai1-K85E binding and Orai1-K85E ...
Effect of molecular knockdown of Orai1, STIM1, or PLA2g6 on the ...
| The Orai-ANSGA mutation restores ion selectivity to the Orai1-V102C ...
Frontiers | Orai1-mediated store-operated Ca2+ entry promotes cervical ...
L-type Ca2+ channel activation of STIM1–Orai1 signaling remodels the ...
SOCE blockers reduce RV-induced Ca 2+ signaling. (A) Relative mRNA ...
Distinct pharmacological profiles of ORAI1, ORAI2, and ORAI3 channels - PMC
