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Structural basis for inhibition of the lysosomal two-pore channel TPC2 ...
TPC2 controls pigmentation by regulating melanosome pH and size | PNAS
溶酶体 TPC2 和 TRPML1 生成的自主 Ca2+ 纳米域的光学分析,Cell Calcium - X-MOL
Hypoxia-induced TPC2 transcription and glycosylation aggravates ...
TPC2 agonists synergistically activate TPC2 a Differential effects of ...
TPC2 targeted to the plasma membrane is uncoupled from ryanodine ...
Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in ...
Frontiers | Endolysosomal Ca2+ Signaling in Cancer: The Role of TPC2 ...
Figure 1 from TPC1 and TPC2 Promote Osteoclastogenesis | Semantic Scholar
Targeting TPC2 sensitizes acute lymphoblastic leukemia cells to ...
TPC2 mediates new mechanisms of platelet dense granule membrane ...
Activation of single Ca 2-permeable TPC2 channels by NAADP. A, typical ...
TPC2 promotes choroidal angiogenesis and inflammation in a mouse model ...
Diagrammatic depiction of TPC2 role in metabolic reprogramming in ...
Silencing TPC2 expression attenuates the rate and extent of Ca 2+ in fl ...
TPC2 is the pore-forming subunit of an NAADP-gated channel. A ...
The endosomal calcium channels TPC1 and TPC2 are necessary for EBOV ...
Role of lysosomal channel protein TPC2 in osteoclast differentiation ...
Levels of TPC1 and TPC2 mRNA relative to β-actin mRNA (A). Western-blot ...
TPCs are N-glycosylated. A, schematic depictions of TPC1 and TPC2 ...
Correlation of endogenous TPC1 and TPC2 expression with cell cycle ...
TPC2 and TRPML1 channels generate independent Ca 2þ nanodomains. Ca 2 ...
| Schematic representation of the role of TPC2 in the... | Download ...
Effect of TPC2 overexpression on autophagy. A , overlaid confocal ...
The role of genetic polymorphisms in endolysosomal ion channels TPC2 ...
Neurodegenerative Lysosomal Storage Disorders: TPC2 Comes to the Rescue!
Crosstalk between TPC2 and IP3R regulates Ca2+ signals: Trends in Cell ...
TPC1 and TPC2 are not expressed in the plasma membrane in MEG01 and ...
Agonist-mediated switching of ion selectivity in TPC2 differentially ...
TPC2 regulates melanosomal pH to modulate pigmentation. (a) Histogram ...
Expression of TPC2 pore-only proteins. (A,B) Western blots against ...
GECI fusion to an activated TPC2 is obligatory for detecting TPC2 Ca 2þ ...
Segregated cation flux by TPC2 biases Ca2+ signaling through lysosomes ...
Removal of the N terminus redirects TPC2 from lysosomes to the plasma ...
OCA2 deficiency enhances TPC2 channel activity to reduce melanosomal pH ...
Inhibition of the human TPC2 channel by PI-103 a The chemical ...
TPC2 targeting evolution: Leveraging therapeutic opportunities for ...
Targeting TPC2 activity affects histamine-evoked P-selectin cell ...
TPC2 agonists differentially affect lysosomal pH and proton ...
TPC2 knockdown inhibited neuronal differentiation from mouse ES cells ...
A gain-of-function TPC2 variant R210C increases affinity to PI(3,5)P2 ...
TPC2 expression and NAADP-evoked Ca2+ signalling.A–C, Effect of ...
The growth and developmental phenotypes of tpc2 − cells are dependent ...
tPC2 signaling inhibited autophagy by increasing lysosomal ph in heLa ...
TPC2 promotes the formation of tubule connections between PDGs. (A ...
Inside-out recordings of plasma membrane-targeted TPC2 show altered ...
Cation permeability of TPC2 is independently regulated a Effect of ...
Early developmental responses are altered in tpc2 − cells. a Schematic ...
Diagrammatic depiction of TPC2 role in metastatic melanoma. The ...
TPC2 polymorphisms associated with a hair pigmentation phenotype in ...
TPC2 signaling inhibited the progression of autophagy during neural ...
Co-activation of TPC2 regulates lysosomal function a Effect of ...
Functionality of TPC2 pore-only proteins in live cells. (A) Confocal ...
Frontiers | Two-pore channel regulators - Who is in control?
Targeting the two-pore channel 2 in cancer progression and metastasis
TPC2: a promising target for drug development | Pharmacological ...
Frontiers | Endolysosomal transient receptor potential mucolipins and ...
Ca 2 , not mTOR, was involved in TPC2-induced autophagosome ...
Adrenaline stimulates glucagon secretion by Tpc2-dependent Ca2 ...
Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic ...
Schematic drawings for the state transitions in TPC3 and TPC2. (A ...
A Role for Two-Pore Channel Type 2 (TPC2)-Mediated Regulation of ...
TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion ...
TRPML1 does not affect NAADP-mediated channel activity of TPC2. Single ...
P-selectin-dependent leukocyte adhesion is governed by endolysosomal ...
The Two-pore channel (TPC) interactome unmasks isoform-specific roles ...
Rabbit TPC1, TPC2, and TPC3 are distantly related and exhibit ...
Small molecule agonist TPC2-A1-N increases intracellular Ca2 ...
Rabbit TPC1, TPC2, and TPC3 display different selectivities for ...
Altered properties of acidic vesicles in tpc2⁻ cells. a Intracellular ...
Gene editing and synthetically accessible inhibitors reveal role for ...
Mapping the topology of TPCs with anti-peptide antibodies. A, schematic ...
Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by ...
TPCs are intracellular proteins targeted to the endolysosomal system ...
Developmental delay of tpc2⁻ cells. Parental Ax2 and tpc2⁻ cells were ...
Schematic of the naaDP/tPC2/Ca 2+ pathway-mediated inhibition of ...
Tissue and subcellular expression of mammalian TPC2.a, Hydropathy plot ...
Modelled structure of human TPC2. The structure is modelled with ...
(a) Projected band diagram of a heterostructure of TPC1/TPC2 along the ...
